Comparision Efficacy of Hydrocortisone Acetate Cream in Patients

In a double-blinded, randomized, clinical trial lasting two weeks in 20 patients with skin infections (Eczema, Dermatitis, and pruritus), inflammatory and Pruritic manifestations of corticosteroid responsive dermatoses Pruritus, Eczema and Atopic Dermatitis were treated and compared between 1% w/w hydrocortisone cream and reference 1% w/w cutisoft hydrocortisone acetate cream and reductions of the basic criteria, i.e. itching, erythema and scaling, were evaluated. Effects were compared using Visual Analogue Scale, Patients compliance and Physician Global Evaluation of efficacy. All treatment regimens significantly reduced itching, erythema and scaling after 4 visits. The patients were assessed on day 01 (Visit 1), day 05 + 01 (Visit 2), day 10 + 01 (Visit 3) and on day 14 + 01 (Visit 4) for the analyses of infection. The basic criteria scores were decreased from visit 1 to visit 4. All patients were well tolerated. The results of therapeutic outcome proved the better results for test cream over reference cuti soft cream, the statistical analysis based on Generalized Linear model shown that both the products are clinically equivalent in terms of anti-inflammatory effect of hydrocortisone cream in this study.